EFFECT OF POLYPHENOL COMPOUNDS ON LIVER MITOCHONDRAL ATGF-dependent POTASSIUM CHANNEL ACTIVITY IN CCL4-INDUCED TOXIC HEPATITIS
Abstract
Hepatoprotective agents have a pronounced therapeutic effect in acute hepatitis models (poisoning with CCl4, paracetamol, D-galactosamine, and allyl). Hepatoprotective agents prevent the death of animals, inflammatory infiltration of the stroma, the development of necrosis, protein and lipid degeneration of hepatocytes, and help restore the function of their specific organelles, such as the endoplasmic reticulum, mitochondria, and lysosomes. Toxic hepatitis leads to an imbalance between oxidative phosphorylation and antioxidant systems in liver mitochondria. Increased free radical concentration due to impaired electron transport through respiratory chain complexes alters the permeability of mitochondrial ion channels. Under conditions of toxic hepatitis or excessive oxidative stress, activation or inhibition of the ion transport systems of the inner membrane of liver mitochondria can occur. Mitochondrial ion channels are identified as targets for the majority of currently available drugs.
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