PREVENTING ADVERSE OUTCOMES OF ISCHEMIC STROKE IN PATIENTS WITH TYPE II DIABETES MELLITUS: A COMPARATIVE STUDY
Keywords:
Ischemic stroke, Type II diabetes mellitus, glycemic controlAbstract
Ischemic stroke in the setting of Type II Diabetes Mellitus presents several unique challenges, reflected in increased complication rates and poorer long-term outcomes. This review will attempt to point out possible strategies for avoiding adverse outcomes in patients with ischemic stroke and concomitant DM-2. 256 patients with IS were investigated: MG consisted of 124 patients who presented with IS and DM-2, and CG included 132 patients with IS who did not have DM-2. According to the results obtained, it can be concluded that proper blood glucose control, early thrombolysis, and rehabilitation measures adapted to the individual features of a patient may weaken the noxious effects of ischemic stroke in patients with DM-2. Besides, addressing underlying cardiovascular risk factors and optimizing pharmacological therapy are both vital in the improvement of clinical outcomes in this high-risk population.
References
Almdal T. et al. The independent effect of type 2 diabetes mellitus on ischemic heart disease, stroke, and death: a population-based study of 13 000 men and women with 20 years of follow-up //Archives of internal medicine. – 2004. – Т. 164. – №. 13. – С. 1422-1426.
Bonnet F., Scheen A. J. Impact of glucose-lowering therapies on risk of stroke in type 2 diabetes //Diabetes & metabolism. – 2017. – Т. 43. – №. 4. – С. 299-313.
Azevedo J. R. A. et al. Management of hyperglycemia in patients with acute ischemic stroke: comparison of two strategies //Critical Care. – 2009. – Т. 13. – С. 1-1.
Nguyen L. et al. Dextromethorphan: An update on its utility for neurological and neuropsychiatric disorders //Pharmacology & therapeutics. – 2016. – Т. 159. – С. 1-22.
Can Ö. D. et al. The effect of agomelatine treatment on diabetes-induced cognitive impairments in rats: concomitant alterations in the hippocampal neuron numbers //International Journal of Molecular Sciences. – 2018. – Т. 19. – №. 8. – С. 2461.
Ha J. et al. Pioglitazone use and reduced risk of dementia in patients with diabetes mellitus with a history of ischemic stroke //Neurology. – 2023. – Т. 100. – №. 17. – С. e1799-e1811.
Ali M. R. et al. Aspect of thrombolytic therapy: a review //The Scientific World Journal. – 2014. – Т. 2014. – №. 1. – С. 586510.